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Product Name
THOC2 antibody
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Description
THOC2 Rabbit Polyclonal antibody. Positive IF detected in HeLa cells. Positive WB detected in HeLa cells, Jurkat cells. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 150 kDa
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Tested applications
ELISA, IP, WB, IF
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Species reactivity
Human; other species not tested.
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_020449). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IP: 1:200-1:1000
IF: 1:20-1:200
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:116047(THoc2 Antibody) at dilution of 1:300
IP Result of anti-THoc2 (IP:Catalog No:116047, 5ug; Detection:Catalog No:116047 1:300) with HeLa cells lysate 1800ug.
Immunofluorescent analysis of HeLa cells using Catalog No:116047(THoc2 Antibody) at dilution of 1:50 and Rhodamine-Goat anti-Rabbit IgG
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Background
THoc2 also termed as THO complex 2 or CXorf3 is 1593 amino acid protein, which belongs to the THoc2 family. THoc2 is a component of heteromultimeric THO/TREX (transcription/export) complex, which is a multi-protein structure consisting of THoc1, THoc2, THoc3, BAT1 and ALY. The TREX complex associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism.
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References
- Sakuma T, Tonne JM, Ikeda Y. Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts. Viruses. 6(3):1135-48. 2014.
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