TGIF2 antibody

TGIF2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TGIF2 Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 26kd

ELISA, IF, WB

Human,Mouse,Rat; other species not tested.

5 TG 3 interacting factor 2 antibody; Homeobox protein TGIF2 antibody; TGFB induced factor 2 antibody; TGFB induced factor homeobox 2 antibody; TGIF2 antibody

Rabbit IgG

This antibody was obtained by immunization of TGIF2 recombinant protein (Accession Number: NM_001199515). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Transforming growth factor-beta-induced factor 2(TGIF2), is a member of a subfamily of transcription factor with a TALE(3-amino acid loop extension), a atypical homeodomain. It also contains a proline-rich region, which is a putative SH3 domain-binding site and suggested involve in transcriptional regulation. It is highly expressed in heart, kidney and testis, but low in brain and prostate. Through binding directly to the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins , TGIF2 acts as a transcriptional repressor. The calculated molecular weight of TGIF2 is 26 kDa, but the phosphorylated TGIF2 is a about 38 kDa protein.

• Lee BK, Shen W, Lee J. Tgif1 Counterbalances the Activity of Core Pluripotency Factors in Mouse Embryonic Stem Cells. Cell reports. 13(1):52-60. 2015.