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Product Name
TFIIE beta antibody
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Description
TFIIE beta Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, A375 cells. Observed molecular weight by Western-blot: 34kd
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
GTF2E2 antibody; TF2E2 antibody; TFIIE B antibody; TFIIE beta antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TFIIE beta recombinant protein (Accession Number: XM_024447138). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:116013(TFIIE beta antibody) at dilution of 1:800
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Background
The general transcription factor IIE (TFIIE) is an essential component of the eukaryotic RNA polymerase II initiation complex, which plays pivotal roles in initiation of protein-coding gene transcription (PMID: 7829083). Transcription initiation factor IIE comprises two subunits, TFIIE-alpha and TFIIE-beta, two chains of which together form a tetramer. TFIIE-beta is encoded by GTF2E2 gene and contains TFIIE beta-DNA binding domain. It mainly functions to recruit TFIIH to the initiation complex and stimulate RNA polymerase II kinase activity (PMID: 10792464).
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References
- De Cegli R, Iacobacci S, Flore G. Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation. Nucleic acids research. 41(2):711-26. 2013.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"