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Product Name
TEAD2 antibody
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Description
TEAD2 Rabbit Polyclonal antibody. Positive WB detected in mouse colon tissue, mouse lung tissue. Observed molecular weight by Western-blot: 55-65 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
ETF antibody; TEA domain family member 2 antibody; TEAD 2 antibody; TEAD2 antibody; TEF 4 antibody; TEF4 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TEAD2 recombinant protein (Accession Number: XM_047439527). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
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Validations
mouse colon tissue were subjected to SDS PAGE followed by western blot with Catalog No:115932(TEAD2 Antibody) at dilution of 1:300
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Background
TEAD2 belongs to a protein family that share the TEA/ATTS domain. It acts as a transcriptional factor by cooperatively binding to the GT-IIC and Sph(I 1 II) enhansons in the simian virus 40 (SV40) enhancer. Also it can modulate SV40 late transcription together with large T antigen. The transcriptional activity of TEAD2 required several regions of the proteins , a TBP-associated factors and a limiting transcriptional intermediary facotrs. TEAD2 also preforms an essential role in the Hippo signaling pathway. TEAD2 regulates gene rexpression of YAP1 and WWTR1/TAZ, thus mediating cell proliferation, migration and epithelial mesenchymal transition induction. TEAD2 is strongly expressed in human ovarian carcinoma cell line.
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References
- Zhang D, Wang X, Li Y. Thyroid hormone regulates muscle fiber type conversion via miR-133a1. The Journal of cell biology. 207(6):753-66. 2014.
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