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TCL1A antibody

Cat.#: 115911

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Product Information

  • Product Name
    TCL1A antibody
  • Documents
  • Description
    TCL1A Rabbit Polyclonal antibody. Positive WB detected in Raji cells. Positive IHC detected in human tonsillitis tissue, human lung cancer tissue. Observed molecular weight by Western-blot: 14-16kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    Oncogene TCL 1 antibody; Oncogene TCL1 antibody; Protein p14 TCL1 antibody; T cell leukemia/lymphoma 1A antibody; TCL1 antibody; TCL1A antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of TCL1A recombinant protein (Accession Number: XM_017021676). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

    IHC: 1:20-1:200

  • Validations

    Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:115911(TCL1A antibody) at dilution of 1:300

    Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:115911(TCL1A antibody) at dilution of 1:300

    Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:115911(TCL1A Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:115911(TCL1A Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:115911(TCL1A Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:115911(TCL1A Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    TCL1A, also named as TCL1 and p14 TCL1, enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. TCL1A immunodetection is an independent marker of adverse outcome that could be used in routine settings for the management of DLCL patients. TCL1A expression is correlated with shorter time to treatment in chronic lymphocytic leukemia cases and shorter lymphoma-specific survival in mantle cell lymphoma series. It is a potential therapeutic target.
  • References
    • E Q, Tang M, Zhang X. Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells. Cell biology international. 39(12):1418-24. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"