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Product Name
TCEAL7 antibody
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Description
TCEAL7 Rabbit Polyclonal antibody. Positive WB detected in human liver tissue, A549 cells. Positive IHC detected in human ovary tumor. Observed molecular weight by Western-blot: 12 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
human; other species not tested.
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Alternative names
TCEAL7 antibody; TCEA like protein 7 antibody; MPMGp800C04260Q003 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TCEAL7 recombinant protein (Accession Number: NM_152278). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:115899(TCEAL7 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human ovary tumor using Catalog No:115899(TCEAL7 antibody) at dilution of 1:50 (under 40x lens)
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Background
TCEAL7 is a transcription regulatory factor that has a role in the negative regulation of NF-kappa-B signaling at the basal level by regulating transcriptional activity of NF-kappa-B on its target gene promoters. It can associate with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. In addition, TCEAL7 regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines
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References
- Huang CY, Chen YM, Zhao JJ. Decreased expression of transcription elongation factor A-like 7 is associated with gastric adenocarcinoma prognosis. PloS one. 8(1):e54671. 2013.
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