TBXAS1 antibody

Cat.#: 115895

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Product Information

  • Product Name
    TBXAS1 antibody
  • Documents
  • Description
    TBXAS1 Rabbit Polyclonal antibody. Positive WB detected in A549 cells, human colon tissue. Positive IHC detected in human lung cancer tissue. Observed molecular weight by Western-blot: 60 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    CYP5 antibody; CYP5A1 antibody; CytOChrome P450 5A1 antibody; GHOSAL antibody; TBXAS1 antibody; THAS antibody; Thromboxane A synthase antibody; TXA synthase antibody; TXAS antibody; TXS antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of TBXAS1 recombinant protein (Accession Number: NM_001166254). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:115895(TBXAS1 antibody) at dilution of 1:500

    A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:115895(TBXAS1 antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115895(TBXAS1 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115895(TBXAS1 antibody) at dilution of 1:50 (under 10x lens)

  • Background
    TBXAS1 catalyzes the conversion of the prostaglandin endoperoxide into thromboxane A2 as a potent vasoconstrictor and inducer of platelet aggregation.It was identified as novel airway fibroblast-specific markers with integrin-8 (ITGA8) (PMID:20435685). It was observed in the epithelium.It is a monomer with the molecular weight of 60 KDa. It also has two variants with 60.5 kDa and 52.3 kDa (PMID:1730669). It also reavels a molecular weight of 55 kDa in humen uterus (PMID:1386258).
  • References
    • Singh SR, Billington CK, Sayers I, Hall IP. Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways? American journal of physiology. Lung cellular and molecular physiology. 299(2):L169-83. 2010.
    • Mousa AA, Strauss JF, Walsh SW. Reduced methylation of the thromboxane synthase gene is correlated with its increased vascular expression in preeclampsia. Hypertension. 59(6):1249-55. 2012.
    • Singh SR, Billington CK, Sayers I, Hall IP. Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity. Respiratory research. 15:57. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"