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Product Name
TAOK3 antibody
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Description
TAOK3 Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue. Positive IP detected in HepG2 cells. Positive WB detected in human liver tissue, HeLa cells, HepG2 cells, human brain tissue. Observed molecular weight by Western-blot: 100-105 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
DKFZp666H245 antibody; DPK antibody; FLJ31808 antibody; hKFC A antibody; JIK antibody; JNK/SAPK inhibitory kinase antibody; Jun kinase inhibitory kinase antibody; KDS antibody; Kinase from chicken homolog A antibody; MAP3K18 antibody; TAO kinase 3 antibody; TAOK3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TAOK3 recombinant protein (Accession Number: XM_047428948). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:115849(TAOK3 antibody) at dilution of 1:800
Immunohistochemical of paraffin-embedded human liver using Catalog No:115849(TAOK3 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver using Catalog No:115849(TAOK3 antibody) at dilution of 1:50 (under 40x lens)
IP Result of anti-TAOK3 (IP:Catalog No:115849, 4ug; Detection:Catalog No:115849 1:700) with HepG2 cells lysate 3600ug.
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Background
TAOK3(Serine/threonine-protein kinase TAO3) is also named as DPK, JIK, KDS, MAP3K18 and belongs to the STE Ser/Thr protein kinase family. It acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, it is involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. And this protein can be autophosphorylated(PMID:20949042).
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