-
Product Name
SYTL4 antibody
- Documents
-
Description
SYTL4 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue. Positive WB detected in Transfected HEK-293 cells.
-
Tested applications
ELISA, WB, IHC
-
Species reactivity
Human,Mouse,Rat; other species not tested.
-
Alternative names
DKFZp451P0116 antibody; Exophilin 2 antibody; FLJ40960 antibody; Granuphilin antibody; SLP4 antibody; synaptotagmin like 4 antibody; Synaptotagmin like protein 4 antibody; SYTL4 antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of SYTL4 recombinant protein (Accession Number: NM_001370167). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
-
Validations
Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:115962(SYTL4 Antibody) at dilution of 1:800
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115962(SYTL4 antibody) at dilution of 1:50 (under 10x lens)
-
Background
SYTL4, also known as SLP4 or granuphilin, is a member of the synaptotagmin-like protein (Slp) family. Members of this family are characterized by presence of an N-terminal Slp homology domain (SHD), which functions as a Rab27-binding domain, and C-terminal tandem C2 domains, putative Ca(2+)-binding motifs. SYTL4 is specifically expressed on dense-core granules in certain neuroendocrine cells and negatively controls dense-core vesicle exocytosis through specific interaction with Rab27A. (PMID: 16481396; 16473610)
-
References
- Wu HY, Tseng VS, Chen LC. Identification of tyrosine-phosphorylated proteins associated with lung cancer metastasis using label-free quantitative analyses. Journal of proteome research. 9(8):4102-12. 2010.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"