Cart 2

Syntaxin 11 antibody

Cat.#: 115791

Size:

Special Price 239.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Syntaxin 11 antibody
  • Documents
  • Description
    Syntaxin 11 Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma tissue. Positive WB detected in human placenta tissue, DU 145 cells, human skeletal muscle tissue, Jurkat cells, L02 cells, mouse lung tissue. Observed molecular weight by Western-blot: 35 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    FHL4 antibody; HLH4 antibody; HPLH4 antibody; STX11 antibody; syntaxin 11 antibody; Syntaxin 11 antibody; SYX11 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Syntaxin 11 recombinant protein (Accession Number: XM_047419437). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:115791(STX11 antibody) at dilution of 1:400

    human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:115791(STX11 antibody) at dilution of 1:400

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:115791(STX11 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:115791(STX11 antibody) at dilution of 1:100 (under 10x lens)

  • Background
    Syntaxin 11 (STX11) belongs to the syntaxin family. It interacts with the SNARE proteins SNAP-23 and VAMP. STX11 behaves as an integral membrane protein despite the lack of a traditional transmembrane domain. The detection of STX11 in human cytotoxic lymphocytes suggests that this protein could play a role in the process leading to degranulation of secretory lysosomes (PMID:17525286).
  • References
    • Marsh RA, Satake N, Biroschak J. STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America. Pediatric blood & cancer. 55(1):134-40. 2010.
    • Kawashima R, Ikematsu K, Abe Y. Effect of glucocorticoid on the biosynthesis of growth hormone-containing secretory granules in pituitary cells. Biochemical and biophysical research communications. 400(2):225-9. 2010.
    • Bin NR, Jung CH, Piggott C, Sugita S. Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation. Proceedings of the National Academy of Sciences of the United States of America. 110(12):4610-5. 2013.
    • Cichocki F, Schlums H, Li H. Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency. The Journal of experimental medicine. 211(6):1079-91. 2014.
    • Hellewell AL, Foresti O, Gover N, Porter MY, Hewitt EW. Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells. PloS one. 9(6):e98900. 2014.
    • Bin NR, Jung CH, Kim B. Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis. Journal of cell science. 128(10):1946-60. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"