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Product Name
SYNGAP1 antibody
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Description
SYNGAP1 Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 148 kDa
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Tested applications
ELISA, WB, IF, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
DKFZp761G1421 antibody; KIAA1938 antibody; MRD5 antibody; Neuronal RasGAP antibody; RASA1 antibody; RASA5 antibody; Synaptic Ras GAP 1 antibody; SYNGAP antibody; SYNGAP1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_006772). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:1000-1:10000
IP: 1:200-1:2000
IF: 1:10-1:100
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:115783(SYNGAP1 antibody) at dilution of 1:500
Immunofluorescent analysis of HepG2 cells, using SYNGAP1 antibody Catalog No:115783 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
IP Result of anti-SYNGAP1 (IP:Catalog No:115783, 4ug; Detection:Catalog No:115783 1:500) with mouse brain tissue lysate 4000ug.
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Background
SYNGAP1, also named as KIAA1938, is the major constituent of the PSD essential for postsynaptic signaling. It’s an inhibitory regulator of the Ras-cAMP pathway. SYNGAP1 is a member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. SYNGAP1 regulates AMPAR-mediated miniature excitatory postsynaptic currents. SYNGAP1 may be involved in certain forms of brain injury, leading to long-term learning and memory deficits Defects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5).
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