SUPT6H antibody

SUPT6H antibody

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• Material Safety Data Sheets (MSDS)

SUPT6H Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HEK-293 cells, Jurkat cells. Positive IP detected in HEK-293 cells. Observed molecular weight by Western-blot: 230 kDa

ELISA, WB, IP

Human,Mouse,Rat; other species not tested.

emb 5 antibody; hSPT6 antibody; KIAA0162 antibody; SPT6 antibody; SPT6H antibody; SUPT6H antibody; Tat cotransactivator 2 protein antibody; Tat CT2 protein antibody

Rabbit IgG

This antibody was obtained by immunization of SUPT6H recombinant protein (Accession Number: XM_047436600). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

SUPT6H (suppressor of Ty6 homolog), also known as SPT6, SPT6H, Tat-CT2 (Tat-cotransactivator 2 protein) or emb-5 in C. elegans, is a 1,726 amino acid protein that is highly conserved from yeast to humans. Expressed ubiquitously, SUPT6H localizes to the nucleus and contains one SH2 domain and one S1 domain. SUPT6H participates in both DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole)-mediated transcriptional inhibition as well as the enhancement of transcriptional elongation by the RNA polymerase II (Pol II). SUPT6H interacts with the nuclear proteins SPT4 and SPT5, which comprise the DSIF (DRB-sensitivity-inducing factor) complex that binds RNA polymerase II, and directly regulates elongation. Via its C-terminus, SUPT6H can also interact with Histone H3. Due to alternative splicing events, three isoforms exist for SUPT6H. This antibody specifically recognizes the 230kd phosphorylated SUPT6H protein.