SUPT16H antibody

SUPT16H antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SUPT16H Rabbit Polyclonal antibody. Positive IHC detected in human tonsillitis tissue, human spleen tissue. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 140 kDa

ELISA, WB, IHC, IP

Human, Mouse; other species not tested.

CDC68 antibody; FACT 140 kDa subunit antibody; FACT complex subunit SPT16 antibody; FACT140 antibody; FACTP140 antibody; FLJ10857 antibody; FLJ14010 antibody; FLJ34357 antibody; hSPT16 antibody; SPT16/CDC68 antibody; SUPT16H antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_007192). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

SUPT16H, also named as FACT140, FACTP140, SPT16 and CDC68, belongs to the peptidase M24 family and SPT16 subfamily. SUPT16H is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). It also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. The antibody is specific to SUPT16H.

• Szerlong HJ, Herman JA, Krause CM. Proteomic characterization of the nucleolar linker histone H1 interaction network. Journal of molecular biology. 427(11):2056-71. 2015.