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Product Name
Human UBE2I recombinant protein
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Description
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'.
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Protein name
SUMO-conjugating enzyme UBC9
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Protein short names
C358B7.1; UBCE2I; F830028O17RIK; UBC9; P18; UBCE9; 5830467E05RIK
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Uniprot ID
P63279
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Gene Name
UBE2I; UBC9; UBCE9
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human UBE2I (P63279) (Met 1-Ser 158) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human UBE2I consists of 160 amino acids and migrates as an approximately 18 kDa band in SDS-PAGE under reducing conditions as predicted.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human UBE2I Protein SDS-PAGE
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