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STXBP2 antibody

Cat.#: 115810

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Product Information

  • Product Name
    STXBP2 antibody
  • Documents
  • Description
    STXBP2 Rabbit Polyclonal antibody. Positive IHC detected in human lung cancer tissue, human kidney tissue. Positive WB detected in K-562 cells, Jurkat cells, mouse brain tissue, mouse kidney tissue, rat kidney tissue. Observed molecular weight by Western-blot: 66kd
  • Tested applications
    ELISA, IHC, WB
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    Hunc18b antibody; MUNC18 2 antibody; pp10122 antibody; STXBP2 antibody; STXBP2 protein antibody; syntaxin binding protein 2 antibody; UNC18 2 antibody; UNC18B antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of STXBP2 recombinant protein (Accession Number: NM_001127396). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:115810(STXBP2 antibody) at dilution of 1:1000

    K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:115810(STXBP2 antibody) at dilution of 1:1000

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115810(STXBP2 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115810(STXBP2 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115810(STXBP2 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115810(STXBP2 antibody) at dilution of 1:100 (under 40x lens)

  • Background
    Syntaxin-binding protein 2 (STXBP2, also known as Unc18-2) belongs to the STXBP/unc-18/SEC1 family. STXBP2 is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in the STXBP2 gene are associated with familial hemophagocytic lymphohistiocytosis.
  • References
    • Cichocki F, Schlums H, Li H. Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency. The Journal of experimental medicine. 211(6):1079-91. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"