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Product Name
Mouse SDF-2/SDF2 (His Tag) recombinant protein
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Description
Stromal derived factors (SDFs) are a loosely defined group of molecules that are generated by stromal cells. Two of the stromal derived factors, SDF-1 and SDF-4 belong to the chemokine family. Other SDFs, such as SDF-2 and SDF-5 are not well defined and their biological functions are less known. SDF-2 is first isolated from the mouse stromal cell line ST2 as a secretory protein. The amino acid sequence deduced from the murine clone and the human homolog are conserved more than 92 %, and the aa sequence of SDF-2 shows similarity to those of yeast dolichyl phosphate-D-mannose, protein mannosyltransferases. SDF-1 and its receptor are strongly indicated in the progression of various cancers including breast cancer. SDF-2, SDF2-L1, SDF-4, and SDF-5 are ubiquitously expressed in various cancer cell lines and SDF-2, SDF-4 and SDF-5 are expressed in mammary tissues. These SDFs have prognostic value and warrant further investigation in their biological functions and clinical value.
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Protein name
Stromal cell-derived factor 2
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Protein short names
AI853825; MGC107120; RP23-185A18.8; SDF-2; SDF2
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Uniprot ID
Q9DCT5
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Gene Name
Sdf2
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse SDF2 (Q9DCT5) (Met 1-Leu 211) was expressed?with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse SDF2 consists of 203 amino acids and has a calculated molecular mass of 22.8 kDa. It migrates as an approximately 27 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Mouse SDF2 / SDF-2 Protein (His Tag) SDS-PAGE
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