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Product Name
Human SDF-2/SDF2 (His Tag) recombinant protein
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Description
Stromal derived factors (SDFs) are a loosely defined group of molecules that are generated by stromal cells. Two of the stromal derived factors, SDF-1 and SDF-4 belong to the chemokine family. Other SDFs, such as SDF-2 and SDF-5 are not well defined and their biological functions are less known. SDF-2 is first isolated from the mouse stromal cell line ST2 as a secretory protein. The amino acid sequence deduced from the murine clone and the human homolog are conserved more than 92 %, and the aa sequence of SDF-2 shows similarity to those of yeast dolichyl phosphate-D-mannose, protein mannosyltransferases. SDF-1 and its receptor are strongly indicated in the progression of various cancers including breast cancer. SDF-2, SDF2-L1, SDF-4, and SDF-5 are ubiquitously expressed in various cancer cell lines and SDF-2, SDF-4 and SDF-5 are expressed in mammary tissues. These SDFs have prognostic value and warrant further investigation in their biological functions and clinical value.
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Protein name
SDF2 protein
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Protein short names
AI853825; RP23-185A18.8; MGC107120; SDF-2; SDF2
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Uniprot ID
Q99470
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Gene Name
SDF2; hCG_2039636
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the pro form of human SDF2 (NP_008854.2) (Met 1-Leu 211) was expressed with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The recombinant human SDF2 consists of 204 amino acids after removal of the signal peptide and has a predicted molecular mass of 22.7 kDa. also estimated by SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human SDF2 Protein (His Tag) SDS-PAGE
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