STRAP antibody

STRAP antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

STRAP Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, HeLa cells, HepG2 cells. Positive IP detected in HeLa cells. Positive IHC detected in human ovary tissue, human lung tissue, human placenta tissue, human skin tissue, human testis tissue. Observed molecular weight by Western-blot: 39 kDa

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

MAP activator with WD repeats antibody; MAWD antibody; PT WD antibody; STRAP antibody; UNR interacting protein antibody; UNRIP antibody; WD 40 repeat protein PT WD antibody

Rabbit IgG

This antibody was obtained by immunization of STRAP recombinant protein (Accession Number: NM_007178). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

STRAP (Serine-threonine kinase receptor-associated protein), also known as MAWD, is a ubiquitous WD40 domain protein, common function of which is to provide a suitable scaffold for coordinating multiprotein complex assemblies and thus, regulate a variety of cellular processes like signal transduction, transcriptional regulation, programmed cell death and so on. STRAP plays a role in the cellular distribution of the SMN complex, which is essential for spliceosomal snRNP assembly in the cytoplasm. STRAP inhibits transforming growth factor-beta (TGF-beta) signaling and enhances tumorigenicity via TGF-beta-dependent and -independent mechanisms. STRAP is up-regulated in several cancers and functions as an oncogene. STRAP imparts oncogenic characteristics to cells by promoting ERK and pRb phosphorylation. Moreover, STRAP regulates c-Jun stability by decreasing the ubiquitylation and proteosomal degradation of c-Jun.