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Product Name
STMN3 antibody
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Description
STMN3 Mouse Monoclonal antibody. Positive WB detected in human brain tissue. Observed molecular weight by Western-blot: 21 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
SCG10 like protein antibody; SCLIP antibody; Stathmin 3 antibody; stathmin like 3 antibody; STMN3 antibody
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Isotype
Mouse IgG2b
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Preparation
This antibody was obtained by immunization of STMN3 recombinant protein (Accession Number: NM_015894). Purification method: Protein G purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:107609(STMN3 antibody) at dilution of 1:1000
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Background
Stathmin family phosphoproteins participate in the control of microtubule dynamics and have been proposed to be involved in the control of neuronal differentiation. Neuron specific Stathmin-3 (STMN3) is a novel STAT3 (signal transducer and activator of transcription 3) interacting protein. STAT3 is a key contributor to cancer cell migration and invasion. STMN3 exhibits microtubule-destabilizing activity, which is antagonized by STAT3. SCG10 is a widely studied and recognized neuronal differentiation marker, STMN3 is a SCG10-like protein (SCLIP) and is present from the earliest stages of hippocampal neuron differentiation in culture at vesicle-like structures following dynamic microtubules. RNAi mediated inhibition of this gene resulted in increased axonal branching.
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