STAT4 antibody

Cat.#: 115690

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Product Information

  • Product Name
    STAT4 antibody
  • Documents
  • Description
    STAT4 Rabbit Polyclonal antibody. Positive IHC detected in human cervical cancer tissue, human testis tissue, mouse testis tissue, rat testis tissue. Positive IF detected in HeLa cells. Positive WB detected in HeLa cells, K-562 cells. Observed molecular weight by Western-blot: 86 kDa
  • Tested applications
    ELISA, WB, IHC, IF
  • Species reactivity
    Human, Mouse, Rat; other species not tested.
  • Alternative names
    SLEB11 antibody; STAT4 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: XM_006712719). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

    IF: 1:20-1:200

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:115690(STAT4 antibody) at dilution of 1:1000

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:115690(STAT4 antibody) at dilution of 1:1000

    Immunohistochemical of paraffin-embedded human cervical cancer using Catalog No:115690(STAT4 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human cervical cancer using Catalog No:115690(STAT4 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human cervical cancer using Catalog No:115690(STAT4 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human cervical cancer using Catalog No:115690(STAT4 antibody) at dilution of 1:100 (under 40x lens)

    Immunofluorescent analysis of HeLa cells using Catalog No:115690(STAT4 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of HeLa cells using Catalog No:115690(STAT4 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    The JAK/STAT pathway is an extensive signaling pathway downstream of cytokine receptors. STATs are cytosolic proteins with a common structure consisting of an N-terminal oligomerization domain, which favors formation of STAT dimers, followed by a DNA-binding domain and a C-terminal SRC homology-2 (SH2) domain, which is involved in association between STATs and receptors[PMID:22383755]. Signal Transducer and Activator of Transcription 4 (STAT4) is a transcription factor that is activated by IL-12 signaling and promotes Th1-cell differentiation and IFN-γ production [PMID:21998209].

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"