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Product Name
ST7 antibody
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Description
ST7 Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue, human heart tissue, human lymphoma tissue, human pancreas tissue. Positive IP detected in PC-3 cells. Positive WB detected in mouse brain tissue, HeLa cells, human brain tissue, Jurkat cells, K-562 cells, PC-3 cells. Observed molecular weight by Western-blot: 63 kDa
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Tested applications
ELISA, IHC, IP, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
DKFZp762O2113 antibody; ETS7q antibody; FAM4A antibody; FAM4A1 antibody; HELG antibody; Protein FAM4A1 antibody; Protein HELG antibody; RAY1 antibody; SEN4 antibody; ST7 antibody; TSG7 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ST7 recombinant protein (Accession Number: BC030954). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:1000-1:10000
IP: 1:500-1:5000
IHC: 1:20-1:200
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:115631(ST7 Antibody) at dilution of 1:2000
IP Result of anti-ST7 (IP:Catalog No:115631, 4ug; Detection:Catalog No:115631 1:1500) with PC-3 cells lysate 2640ug.
Immunohistochemical of paraffin-embedded human liver using Catalog No:115631(ST7 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver using Catalog No:115631(ST7 antibody) at dilution of 1:50 (under 40x lens)
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Background
Human ST7 (suppressor of tumorigenicity 7) gene, also called FAM4A1, HELG or RAY1, maps to a region on chromosome 7 identified as an autism-susceptibility locus. ST7 has been proposed to be a tumor suppressor gene with highest expression in heart, liver and pancreas. The product of this gene is a multi-pass membrane protein belonging to the ST7 family, full-length ST7 cDNA has been cloned and verified in cancer cell lines, recent result suggests that ST7 may mediate tumor suppression through the regulation of the genes involved in maintaining the cellular structure of the cell and involved in oncogenic pathways.
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References
- Yan F, Alinari L, Lustberg ME. Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma. Cancer research. 74(6):1752-65. 2014.
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