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Product Name
SSBP1 antibody
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Description
SSBP1 Rabbit Polyclonal antibody. Positive WB detected in A375 cells, mouse pancreas tissue, rat pancreas tissue. Observed molecular weight by Western-blot: 17 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Mt SSB antibody; MtSSB antibody; PWP1 interacting protein 17 antibody; SSBP antibody; SSBP1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of SSBP1 recombinant protein (Accession Number: NM_001256512). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:1000-1:10000
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Validations
A375 cells were subjected to SDS PAGE followed by western blot with Catalog No:115606(SSBP1 antibody) at dilution of 1:500
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Background
SSBP1 is a housekeeping gene involved in mitochondrial biogenesis. it binds preferentially and cooperatively to ss-DNA in the maintainance of genome stability. SSBP1 acted as a homotetramer to stabilize the displaced single strand of the normal and expanded displacement loop (D loop) during mtDNA replication, thus preventing formation of secondary single-stranded DNA structures, which could stop the gamma-DNA polymerase
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References
- Miralles Fusté J, Shi Y, Wanrooij S. In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication. PLoS genetics. 10(12):e1004832. 2014.
- Li H, Ruan Y, Zhang K. Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization. Cell death and differentiation. 23(3):380-92. 2016.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"