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Product Name
SRPX2 antibody
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Description
SRPX2 Mouse Monoclonal antibody. Positive WB detected in pig lung tissue, A549 cells. Observed molecular weight by Western-blot: 53 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human, Pig; other species not tested.
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Alternative names
BPP antibody; CBPS antibody; PMGX antibody; RESDX antibody; SRPUL antibody; SRPX2 antibody
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Isotype
Mouse IgG2b
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Preparation
This antibody was obtained by immunization of SRPX2 recombinant protein (Accession Number: NM_014467). Purification method: Protein A purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
pig lung tissue were subjected to SDS PAGE followed by western blot with (SRPX2 Antibody) at dilution of 1:1000
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Background
SRPX2 (sushi-repeat-containing protein, X-linked 2) is a secreted protein expressed in neurons of the human adult brain, including the rolandic area (PMID: 20874700). Firstly described as sushi-repeat protein up-regulated in leukemia (SPRUL) in leukemia cells with dysregulated expression at the transcriptional level, SRPX2 has been recently shown as a multifunctional protein. SRPX2 is a ligand for uPAR, the urokinase-type plasminogen activator (uPA) receptor (PMID: 18718938). It is involved in seizure disorders, angiogenesis and cellular adhesion (PMID: 22242148; 19667118; 16497722). The involvement of SRPX2 in disorders of language cortex and cognition suggests it has an important role in the perisylvian region critical for language and cognitive development (PMID: 16497722).
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