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Product Name
SPON2 antibody
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Description
SPON2 Rabbit Polyclonal antibody. Positive IHC detected in human prostate cancer tissue, human prostate hyperplasia tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
DIL 1 antibody; DIL1 antibody; M spondin antibody; Mindin antibody; SPON2 antibody; Spondin 2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of SPON2 recombinant protein (Accession Number: NM_001199021). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:115580(SPON2 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:115580(SPON2 antibody) at dilution of 1:50 (under 40x lens)
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Background
SPON2 (Spondin 2), also known as Mindin, is a member of the F-spondin family of secreted extracellular matrix proteins. This protein has been implicated in axon guidance, immune response and adhesion. SPON2 is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (PMID: 14691481). It also functions as an integrin ligand for inflammatory cell recruitment and T-cell priming (PMID: 19153605). Besides, SPON2 has been reported as a prognostic biomarker for ovarian and prostate cancer (PMID: 17490732; 22615945; 23665271).
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