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Product Name
SOX17 antibody
- Documents
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Description
SOX17 Rabbit Polyclonal antibody. Positive WB detected in mouse embryo tissue, C6 cells, PC-3 cells. Observed molecular weight by Western-blot: 44 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse, Rat; other species not tested.
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Alternative names
FLJ22252 antibody; SOX17 antibody; Transcription factor SOX 17 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of SOX17 recombinant protein (Accession Number: BC111365). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
mouse embryo tissue were subjected to SDS PAGE followed by western blot with Catalog No:115513(SOX17 Antibody) at dilution of 1:600
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Background
Transcription factor SOX 17 (SOX17) also named as SRY box 17 is a 414 amino acid protein, which contains one Sox C-terminal domain and one HMG box DNA-binding domain. SOX17 as a transcription regulator binds target promoter DNA and bend the DNA via WNT3A. SOX17 is a marker of endodermal cells and a transcriptional regulator containing a DNA binding domain called the HMG box. In mouse embryos, SOX17 plays critical roles in the growth and differentiation of definitive endodermal cells (PMID: 11973269), the remodeling of endothelial cells (PMID: 16895970), hindgut endoderm expansion with localization of primordial germ cells (PMID: 19371732), and gallbladder/bile duct formation (PMID: 19913509).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"