SNX27 antibody

SNX27 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SNX27 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells. Positive IHC detected in human cervical cancer tissue, human tonsillitis tissue. Observed molecular weight by Western-blot: 52-60kd

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

KIAA0488 antibody; MRT1 antibody; MY014 antibody; SNX27 antibody; Sorting nexin 27 antibody; sorting nexin family member 27 antibody

Rabbit IgG

This antibody was obtained by immunization of SNX27 recombinant protein (Accession Number: BC012184). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Sorting nexin 27 (SNX27), a PDZ domain-containing protein, belongs to the sorting nexin family of proteins. SNX27 promotes recycling of internalized transmembrane proteins from endosomes to the plasma membrane by linking PDZ-dependent cargo recognition to retromer-mediated transport (PMID: 21602791; 23563491). It has been shown that SNX27 deficiency contributes to the synaptic and cognitive deficits by modulating glutamate receptor recycling in Down’s syndrome (PMID: 23524343). SNX27 has also been proposed to have a role in regulating β-amyloid (Aβ) generation by modulating γ-secretase activity, which is a molecular mechanism for Aβ-dependent pathogenesis in both Down’s syndrome and Down’s syndrome (PMID: 25437557).