SN-38 Monoclonal Antibody

Cat.#: 176732

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Special Price 322.6 USD

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Product Information

  • Product Name
    SN-38 Monoclonal Antibody
  • Documents
  • Description
    Product has been tested in direct ELISA.
  • Tested applications
    ELISA
  • Species reactivity
    Chemical
  • Isotype
    Mouse IgG1, κ
  • Preparation
    SN-38 conjugated with BSA. Protein G affinity purified
  • Clonality
    Monoclonal
  • Formulation
    PBS(pH7.4), lyophilized. Reconstitution: Adding sterile water, prepare a stock solution of 2.0 mg/ml.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    ELISA: 1:5,000-1:20,000
  • Validations

    ELISA Binding Assay of Anti-SN-38 Antibody to different proteins.

    ELISA Binding Assay of Anti-SN-38 Antibody to different proteins.

    ELISA analysis of Anti-SN38 Monoclonal Antibody with SN-38 -BSA, SN-38 ADC and BSA. Anti-SN-38 Monoclonal Antibody can bind to SN-38-BSA or SN-38 ADC but not carrier protein.

    ELISA Binding Assay of Anti-SN-38 Antibody

    ELISA Binding Assay of Anti-SN-38 Antibody

    Immobilized SN-38 ADC at 2μg/ /mL (100μL/well) can bind anti-SN-38 mouse monoclonal antibody.

  • Background
    7-Ethyl-10-hydroxycamptothecin (SN38), a highly potent metabolite of irinotecan, has an anticancer efficacy 100–1000 folds more than irinotecan in vitro. SN-38 is a topoisomerase I inhibitor and SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively.
  • References
    • Wallin A, Svanvik J, Holmlund B, Ferreud L, Sun XF. Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. Oncol Rep. 2008 Jun;19(6):1493-8. PMID: 18497955.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"