SMYD3 antibody

SMYD3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SMYD3 Mouse Monoclonal antibody. Positive WB detected in A431 cells, COLO 320 cells, HEK-293 cells, MCF-7 cells. Observed molecular weight by Western-blot: 49 kDa

ELISA, WB

Human; other species not tested.

bA74P14.1 antibody; FLJ21080 antibody; SMYD3 antibody; ZMYND1 antibody; ZNFN3A1 antibody

Mouse IgG1

This antibody was obtained by immunization of SMYD3 recombinant protein (Accession Number: NM_001167740). Purification method: Protein G purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

SMYD3,also name as ZMYND1 and ZNFN3A1, belongs to the histone-lysine methyltransferase family.It is a histone methyltransferase that plays an important role in transcriptional regulation in human carcinogenesis. It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including several oncogenes (e.g., N-myc, CrkL, Wnt10b, RIZ and hTERT) and genes involved in the control of cell cycle.(PMID: 20957523). It plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD3 is frequently overexpressed in different types of cancer cells. It functions as a coactivator of Era and potentiates Era activity in response to ligand. SMYD3 as a new coactivator for ER-mediated transcription, providing a possible link between SMYD3 overexpression and breast cancer. (PMID: 19509295) The common variable number of tandem repeats polymorphism in SMYD3 is a susceptibility factor for some types of human cancer. (PMID:16155568 ) .