SMN (Human-Specific) antibody

Cat.#: 107594

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Product Information

  • Product Name
    SMN (Human-Specific) antibody
  • Documents
  • Description
    SMN (Human-Specific) Mouse Monoclonal antibody. Positive WB detected in Raji cells, HepG2 cells. Positive IP detected in HEK-293 cells. Positive IHC detected in human brain tissue, human heart tissue, human kidney tissue, human liver tissue. Observed molecular weight by Western-blot: 38 kDa
  • Tested applications
    ELISA, WB, IHC, IP
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    C BCD541 antibody; Component of gems 1 antibody; FLJ76644 antibody; Gemin 1 antibody; SMN antibody; SMN1 antibody; SMN1 antibody; SMN antibody; SMN2 antibody; SMNC antibody; SMNT antibody; Survival motor neuron protein antibody
  • Isotype
    Mouse IgG2a
  • Preparation
    This antibody was obtained by immunization of SMN (Human-Specific) recombinant protein (Accession Number: NM_022875). Purification method: Protein A purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IP: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:107594(SMN2 antibody) at dilution of 1:400

    Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:107594(SMN2 antibody) at dilution of 1:400

    Immunohistochemical of paraffin-embedded human brain using Catalog No:107594(SMN2 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:107594(SMN2 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:107594(SMN2 antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:107594(SMN2 antibody) at dilution of 1:50 (under 40x lens)

    IP Result of anti-SMN2 (IP:Catalog No:107594, 4ug; Detection:Catalog No:107594 1:500) with HEK-293 cells lysate 2440ug.

    IP Result of anti-SMN2 (IP:Catalog No:107594, 4ug; Detection:Catalog No:107594 1:500) with HEK-293 cells lysate 2440ug.

  • Background
    The survival of motor neurons (SMN) genes are the disease genes of spinal muscular atrophy (SMA), a common motor neuron degenerative disease. The level of SMN protein correlates with phenotypic severity of SMA. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional, because a large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein. This antibody 60154-1-Ig is specific to human SMN2. It can't recognize mouse and rat SMN.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"