SMN (Human-Specific) antibody

SMN (Human-Specific) antibody

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SMN (Human-Specific) Mouse Monoclonal antibody. Positive WB detected in Raji cells, HepG2 cells. Positive IP detected in HEK-293 cells. Positive IHC detected in human brain tissue, human heart tissue, human kidney tissue, human liver tissue. Observed molecular weight by Western-blot: 38 kDa

ELISA, WB, IHC, IP

Human; other species not tested.

C BCD541 antibody; Component of gems 1 antibody; FLJ76644 antibody; Gemin 1 antibody; SMN antibody; SMN1 antibody; SMN1 antibody; SMN antibody; SMN2 antibody; SMNC antibody; SMNT antibody; Survival motor neuron protein antibody

Mouse IgG2a

This antibody was obtained by immunization of SMN (Human-Specific) recombinant protein (Accession Number: NM_022875). Purification method: Protein A purified.

Monoclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The survival of motor neurons (SMN) genes are the disease genes of spinal muscular atrophy (SMA), a common motor neuron degenerative disease. The level of SMN protein correlates with phenotypic severity of SMA. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional, because a large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein. This antibody 60154-1-Ig is specific to human SMN2. It can't recognize mouse and rat SMN.