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Product Name
SMN (Human,Mouse,Rat) antibody
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Description
SMN (Human,Mouse,Rat) Mouse Monoclonal antibody. Positive WB detected in 293 cells, HepG2 cells, Raji cells. Observed molecular weight by Western-blot: 38 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
C BCD541 antibody; Component of gems 1 antibody; FLJ76644 antibody; Gemin 1 antibody; SMN antibody; SMN1 antibody; SMN1 antibody; SMN antibody; SMN2 antibody; SMNC antibody; SMNT antibody; Survival motor neuron protein antibody
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Isotype
Mouse IgG2b
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Preparation
This antibody was obtained by immunization of SMN (Human,Mouse,Rat) recombinant protein (Accession Number: NM_022875). Purification method: Protein A purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
WB results of Catalog No:107593(anti-SMN2).
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:107593(SMN2 antibody) at dilution of 1:1000
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Background
The survival of motor neurons (SMN) genes are the disease genes of spinal muscular atrophy (SMA), a common motor neuron degenerative disease. The level of SMN protein correlates with phenotypic severity of SMA. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional, because a large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein. This antibody 60154-2-Ig can recognize human,mouse and rat SMN gene.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"