SIRT3 antibody

SIRT3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SIRT3 Rabbit Polyclonal antibody. Positive WB detected in mouse liver tissue, human spleen tissue, mouse kidney tissue, mouse skeletal muscle tissue. Observed molecular weight by Western-blot: 28 kDa

ELISA, WB

Human,Mouse,Rat; other species not tested.

hSIRT3 antibody; SIR2 like protein 3 antibody; SIR2L3 antibody; SIRT3 antibody

Rabbit IgG

This antibody was obtained by immunization of SIRT3 recombinant protein (Accession Number: NM_012239). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) and SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. It is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, including acetyl coenzyme A synthetase 2. SIRT3 is stress-responsive and its increased expression protects myocytes from genotoxic and oxidative stress-mediated cell death. full-length hSIRT3 (44 kDa) is an inert protein and that it is activated inside the mitochondria following deletion of 142 amino acids of the N-terminal segment. This processed form of SIRT3 is approximately 28 kDa and possesses deacetylase activity. The full SIRT3 is a 44 kDa protein and is processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product.