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  • Anti-SIRT3 Rabbit antibody

Anti-SIRT3 Rabbit antibody

Cat.#: 168987

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-SIRT3 Rabbit antibody
  • Documents
  • Description
    SIRT3 Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P
  • Species reactivity
    Human
  • Alternative names
    SIR2L3 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human SIRT3
  • Clonality
    Monoclonal antibody
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

    IHC: 1/50

  • Validations

    Western blot detection of SIRT3 in Jurkat,Hela cell lysates using SIRT3 Rabbit mAb(1:500 diluted).Predicted band size:44kDa.Observed band size:28kDa.

    Western blot detection of SIRT3 in Jurkat,Hela cell lysates using SIRT3 Rabbit mAb(1:500 diluted).Predicted band size:44kDa.Observed band size:28kDa.

  • Background
    Swiss-Prot Acc.Q9NTG7.NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"