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Product Name
SIK1 antibody
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Description
SIK1 Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue, human colon cancer tissue, human stomach tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
MSK antibody; salt inducible kinase 1 antibody; SIK antibody; SIK 1 antibody; SIK1 antibody; SNF1LK antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of SIK1 recombinant protein (Accession Number: NM_173354). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:115229(SIK1 Antibody) at dilution of 1:50 (under 40x lens)
Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:115229(SIK1 Antibody) at dilution of 1:50 (under 10x lens)
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Background
SIK1(Salt-inducible kinase 1) is also named as SIK, SNF1LK and belongs to the CAMK Ser/Thr protein kinase family. It associates constitutively with the NK regulatory complex and is responsible for increases in its catalytic activity following small elevations in intracellular sodium concentrations(PMID:17939993). SIK1 is required for phosphorylation of class II HDACs and for expression of MEF2 target genes in myocytes(PMID:17468767). Defects in SIK1 may be associated with some cancers, such as breast cancers. Loss of SIK1 correlates with poor patient outcome in breast cancers(PMID:19622832).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"