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SGTA antibody

Cat.#: 115176

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Product Information

  • Product Name
    SGTA antibody
  • Documents
  • Description
    SGTA Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, HeLa cells, human skeletal muscle tissue, mouse liver tissue, SH-SY5Y cells. Positive IP detected in HeLa cells. Positive IHC detected in human lung cancer tissue, human liver cancer tissue, human prostate cancer tissue. Observed molecular weight by Western-blot: 34-37 kDa
  • Tested applications
    ELISA, IHC, WB, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Alpha SGT antibody; alphaSGT antibody; aSGT antibody; hSGT antibody; SGT antibody; SGT1 antibody; SGTA antibody; UBP antibody; Vpu binding protein antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of SGTA recombinant protein (Accession Number: NM_003021). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IP: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:115176(SGTA antibody) at dilution of 1:800

    K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:115176(SGTA antibody) at dilution of 1:800

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115176(SGTA antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115176(SGTA antibody) at dilution of 1:50 (under 10x lens)

    IP Result of anti-SGTA (IP:Catalog No:115176, 4ug; Detection:Catalog No:115176 1:1000) with HeLa cells lysate 2480ug.

    IP Result of anti-SGTA (IP:Catalog No:115176, 4ug; Detection:Catalog No:115176 1:1000) with HeLa cells lysate 2480ug.

  • Background
    SGTA represents small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
  • References
    • Walczak CP, Ravindran MS, Inoue T, Tsai B. A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum. PLoS pathogens. 10(3):e1004007. 2014.
    • Philp LK, Butler MS, Hickey TE, Butler LM, Tilley WD, Day TK. SGTA: a new player in the molecular co-chaperone game. Hormones & cancer. 4(6):343-57. 2013.
    • Bagchi P, Walczak CP, Tsai B. The endoplasmic reticulum membrane J protein C18 executes a distinct role in promoting simian virus 40 membrane penetration. Journal of virology. 89(8):4058-68. 2015.
    • Ravindran MS, Bagchi P, Inoue T, Tsai B. A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum Membrane. PLoS pathogens. 11(8):e1005086. 2015.
    • Novosylna O, Jurewicz E, Pydiura N. Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1. Biochimie. 119:137-45. 2015.
    • Kato Y, Ochiai K, Michishita M. Molecular cloning of canine co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) and investigation of its ability to suppress androgen receptor signalling in androgen-independent prostate cancer. Veterinary journal (London, England : 1997). 206(2):143-8. 2015.
    • Azakami D, Nakahira R, Kato Y. The canine prostate cancer cell line CHP-1 shows over-expression of the co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein α. Veterinary and comparative oncology. 2016.
    • Butler MS, Yang X, Ricciardelli C. Small glutamine-rich tetratricopeptide repeat-containing protein alpha is present in human ovaries but may not be differentially expressed in relation to polycystic ovary syndrome. Fertility and sterility. 99(7):2076-83.e1. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"