Rat Serum amyloid P component (His Tag) recombinant protein

Rat Serum amyloid P component (His Tag) recombinant protein

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Serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. As a normal plasma protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid". Serum amyloid P component represents another member of the pentraxin family, a highly conserved group of molecules that may play a role in innate immunity. SAP is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccinations in humans. SAP suppression may be a novel strategy for improving efficacy of human DNA vaccines and requires further clinical investigations.

Serum amyloid P-component

SAP; MGC88159; APCS; PTX2; HEL-S-92N

P23680

Apcs; Ptx2; Sap

Human Cells

A DNA sequence encoding the rat APCS (P23680) (Met 1-Ser 228) was expressed, fused with a polyhistidine tag at the C-terminus.

Rat

The recombinant rat APCS comprises 219 amino acids and predicts a molecular mass of 25.3 kDa. The apparent molecular mass of the rat APCS is approximately 30 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE