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Product Name
SERTAD1 antibody
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Description
SERTAD1 Rabbit Polyclonal antibody. Positive WB detected in SH-SY5Y cells. Observed molecular weight by Western-blot: 25 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CDK4 binding protein p34SEI1 antibody; SEI 1 antibody; SEI1 antibody; SERTA domain containing 1 antibody; SERTAD1 antibody; TRIP Br1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of SERTAD1 recombinant protein (Accession Number: NM_013376). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
SH-SY5Y cells were subjected to SDS PAGE followed by western blot with Catalog No:115211(SERTAD1 Antibody) at dilution of 1:1000
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Background
SERTA domain containing 1 (SERTAD1, synonyms: SEI1, TRIP-Br1) protein is a cyclin-dependent kinase 4 (cdk4)-binding protein and acts as a growth factor sensor and facilitates the formation and activation of cyclin D-CDK complexes in the face of inhibitory levels of INK4 proteins, therefore, antagonizes the activity of p16(INK4a) tumor suppressor. SERTAD1 also suppresses CREB-mediated transcription and regulates cell cycle progression through sequential effects on the transcriptional activity of E2F-responsive promoters during G(1) and S phases.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"