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Product Name
SERPINA6 antibody
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Description
SERPINA6 Rabbit Polyclonal antibody. Positive WB detected in human plasma tissue, A375 cells, HEK-293 cells, L02 cells. Positive IHC detected in human kidney tissue, human hepat℃irrhosis tissue, human liver cancer tissue, human liver tissue. Observed molecular weight by Western-blot: 45 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
CBG antibody; Serpin A6 antibody; SERPINA6 antibody; Transcortin antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of SERPINA6 recombinant protein (Accession Number: NM_001756). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human plasma tissue were subjected to SDS PAGE followed by western blot with Catalog No:115199(Corticosteroid binding globulin Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:115199(Corticosteroid binding globulin Antibody) at dilution of 1:200 (under 10x lens).
Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:115199(Corticosteroid binding globulin Antibody) at dilution of 1:200 (under 40x lens).
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Background
SERPINA6, also known as corticosteroid-binding globulin or CBG, belongs to the serpin family of serine protease inhibitors, and is mainly secreted by the liver. It is an alpha-globulin protein with corticosteroid-binding properties, and involved in obesity and stress sensitivity. It is also the major transport protein for glucorticoids and progestins in the blood of most vertebrates. Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency).
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References
- Acosta-Martin AE, Panchaud A, Chwastyniak M. Quantitative mass spectrometry analysis using PAcIFIC for the identification of plasma diagnostic biomarkers for abdominal aortic aneurysm. PloS one. 6(12):e28698. 2011.
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