-
Product Name
Human PPP3CA (His Tag) recombinant protein
- Documents
-
Description
Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.
-
Protein name
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
-
Protein short names
PP2B ALPHA 1; CNA; 2900074D19RIK; CALN; PROTEIN PHOSPHATASE 3 (FORMERLY 2B); CNA1; CATALYTIC SUBUNIT; CALCINEURIN A ALPHA; 900074D19RIK; MGC106804; PP2BA ALPHA; AI841391; CAM-PRP CATALYTIC SUBUNIT; CN; ALPHA ISOFORM; CALNA1; CCN1; PPP2B; CALMODULIN-DEPENDENT CALCINEURIN A SUBUNIT ALPHA ISOFORM; PROTEIN PHOSPHATASE 2B; SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM; CALNA; AW413465
-
Uniprot ID
Q08209
-
Gene Name
PPP3CA; CALNA; CNA
-
Source/Expression Host
Baculovirus-Insect Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the human PPP3CA (Q08209-1) (Ser2-Gln521) was fused with a polyhistide tag at the N-terminus.
-
Protein Species
Human
-
Molecular weight
The recombinant human PPP3CA consists of 538 amino acids and has a calculated molecular mass of 60.8 kDa. The recombinant protein migrates as an approximately 60 kDa band in SDS-PAGE under reducing conditions.
-
Purity
> 94 % as determined by SDS-PAGE
-
Activity
Using the Octet RED System, the affinity constant (Kd) of human PPPP3CA-His (Cat:500232) bound to Human PPIA-His (Cat:501254) was 0.9 nM.
-
Validations
Human PPP3CA / Protein phosphatase 2B Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"