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Product Name
Human CDC42BPB (His & GST Tag) recombinant protein
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Description
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.
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Protein name
Serine/threonine-protein kinase MRCK beta
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Protein short names
MRCKB; KIAA1124; FLJ44730; DKFZP686H1431; CDC42BPB; FLJ37601
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Uniprot ID
Q9Y5S2
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Gene Name
CDC42BPB; KIAA1124
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the amino acid (Met 1-His 427) of human CDC42BPB (Q9Y5S2) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CDC42BPB/GST chimera consists of 709 amino acids and has a calculated molecular mass of 82.4 kDa. It migrates as an approximately 70 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 94 % as determined by SDS-PAGE
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Activity
No Kinase Activity
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Validations
Human CDC42BPB Protein (His & GST Tag) SDS-PAGE
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