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Product Name
Human SRGN / serglycin (His Tag) recombinant protein
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Description
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
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Protein name
Serglycin
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Protein short names
HEMATOPOIETIC PROTEOGLYCAN CORE PROTEIN; PROTEOGLYCAN PROTEIN CORE FOR MAST CELL SECRETORY GRANULE; SRGN; PROTEOGLYCAN; PLATELET PROTEOGLYCAN CORE PROTEIN; SGC; PRG; PROTEOGLYCAN 1; P.PG; HEMATOPOETIC PROTEOGLYCAN CORE PROTEIN; PPG; SECRETORY GRANULE PROTEOGLYCAN CORE PROTEIN; HEMATOPOETIC PROTEOGLYCAN CORE PEPTIDE; SECRETORY GRANULE PROTEOGLYCAN CORE PEPTIDE; PRG1; SECRETORY GRANULE; GP600; MASTOCYTOMA PROTEOGLYCAN CORE PROTEIN; SERGLYCIN; SERGLYCIN PROTEOGLYCAN
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Uniprot ID
P10124
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Gene Name
SRGN; PRG; PRG1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human SRGN (CAA34900.1) (Met1-Leu158) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SRGN consists of 142 amino acids and predicts a molecular mass of 16.1 KDa. It migrates as an approximately 57 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human Serglycin / SRGN Protein (His Tag) SDS-PAGE
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