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Product Name
Anti-SRGN / serglycin antibody
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Description
Rabbit polyclonal to SRGN / serglycin
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Tested applications
ELISA, WB
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Species reactivity
Human SRGN / serglycin
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Alternative names
PRG antibody; PRG1 antibody; hematopoetic proteoglycan core peptide antibody; hematopoetic proteoglycan core protein antibody; hematopoietic proteoglycan core protein antibody; p.PG antibody; platelet proteoglycan core protein antibody; proteoglycan 1 antibody; secretory granule antibody; proteoglycan protein core for mast cell secretory granule antibody; secretory granule proteoglycan core peptide antibody; secretory granule proteoglycan core protein antibody; serglycin proteoglycan antibody; Serglycin antibody; Srgn antibody; Prg antibody; Prg1 antibody; Sgc antibody; gp600 antibody; mastocytoma proteoglycan core protein antibody; proteoglycan 1 antibody; secretory granule antibody; proteoglycan antibody; secretory granule antibody; secretory granule proteoglycan core protein antibody; PPG antibody; PRG antibody; PRG1 antibody; Prg antibody; Sgc antibody; Prg1 antibody; Serglycin antibody; SRGN antibody; PPG antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human SRGN / serglycin (rh SRGN / serglycin; CAA34900.1; Met1-Leu158). SRGN / serglycin specific IgG was purified by Human SRGN / serglycin affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-50 μg/ml
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human SRGN / serglycin. The detection limit for Human SRGN / serglycin is < 0.039 ng/well.
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Validations
SRGN / serglycin Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"