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Secretogranin III antibody

Cat.#: 115096

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Product Information

  • Product Name
    Secretogranin III antibody
  • Documents
  • Description
    Secretogranin III Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue. Positive WB detected in HeLa cells. Observed molecular weight by Western-blot: 50-53 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    SCG3 antibody; Secretogranin 3 antibody; secretogranin III antibody; SGIII antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Secretogranin III recombinant protein (Accession Number: NM_013243). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:115096(SCG3 antibody) at dilution of 1:500

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:115096(SCG3 antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:115096(SCG3 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:115096(SCG3 antibody) at dilution of 1:50 (under 10x lens)

  • Background
    Secretogranin III (SCG3), a member of the granin protein family, is expressed specifically in neuronal and endocrine cells.SCG3 was synthesized as a 61- or 63-kDa protein and processed to a 48-kDa form which, in turn, was partially cleaved to fragments of 28 and 20 kDa.
  • References
    • Hotta K, Hosaka M, Tanabe A, Takeuchi T. Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC. The Journal of endocrinology. 202(1):111-21. 2009.
    • Paco S, Pozas E, Aguado F. Secretogranin III is an astrocyte granin that is overexpressed in reactive glia. Cerebral cortex (New York, N.Y. : 1991). 20(6):1386-97. 2010.
    • Plá V, Paco S, Ghezali G. Secretory sorting receptors carboxypeptidase E and secretogranin III in amyloid β-associated neural degeneration in Alzheimer's disease. Brain pathology (Zurich, Switzerland). 23(3):274-84. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"