SCNN1G antibody

SCNN1G antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SCNN1G Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue. Positive WB detected in mouse lung tissue. Observed molecular weight by Western-blot: 70-85 kDa

ELISA, IHC, WB

Human,Mouse,Rat; other species not tested.

ENaCg antibody; ENaCgamma antibody; Gamma ENaC antibody; Gamma NaCH antibody; PHA1 antibody; SCNEG antibody; SCNN1G antibody

Rabbit IgG

This antibody was obtained by immunization of SCNN1G recombinant protein (Accession Number: NM_001039). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

SCNN1G (sodium channel, nonvoltage-gated 1, gamma), also known as ENaC gamma (epithelial Na(+) channel subunit gamma) or amiloride-sensitive sodium channel subunit gamma, is the gamma subunit of the epithelial Na(+) channel (ENaC). ENaC is expressed in the apical membrane of salt-absorbing epithelia of kidney, distal colon, and lung. ENaC is a non-voltage gated, constitutively active channel highly selective for sodium. It has an essential role in salt and fluid homeostasis across epithelial tissues. Mutations in the gene of SCNN1G have been associated with Liddle syndrome. Native SCNN1G has a calculated molecular weight of 74 kDa and maybe undergo post-transcriptional modifications, including glycosylation and proteolytic cleavage (PMID: 12871941; 18086683).

• Wang S, He G, Yang Y. Reduced expression of Enac in Placenta tissues of patients with severe preeclampsia is related to compromised trophoblastic cell migration and invasion during pregnancy. PloS one. 8(8):e72153. 2013.