SCN9A/Nav1.7-Specific antibody

SCN9A/Nav1.7-Specific antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SCN9A/Nav1.7-Specific Rabbit Polyclonal antibody. Positive WB detected in A431 cells. Positive IF detected in PC-12 cells. Positive IHC detected in human brain tissue. Observed molecular weight by Western-blot: 228kd

ELISA, WB, IF, IHC

Human; other species not tested.

ETHA antibody; hNE Na antibody; Nav1.7 antibody; NE NA antibody; NENA antibody; NeuroendOCrine sodium channel antibody; Peripheral sodium channel 1 antibody; PN1 antibody; SCN9A antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_002977). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

SCN9A, also named as NENA, PN1, ETHA, NE-NA, Nav1.7 and hNE-Na, belongs to the sodium channel family. SCN9A mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, SCN9A forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na+ channel isoform. SCN9a plays a role in pain mechanisms, especially in the development of inflammatory pain. Defects in SCN9A are the cause of primary erythermalgia or autosomal recessive congenital indifference to pain or paroxysmal extreme pain disorder (PEPD). The antibody is specific to SCN9A