RYR2 Polyclonal Antibody

Cat.#: 160054

Special Price 174.2 USD

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Product Information

  • Product Name
    RYR2 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to RYR2
  • Tested applications
    WB, IHC, IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    RYR2 antibody; ARVC2 antibody; ARVD2 antibody; RYR-2 antibody; RyR antibody; VTSIP antibody; ryanodine receptor 2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide corresponding to a sequence within amino acids 4850-4950 of human RYR2 (NP_001026.2).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IHC 1:50 - 1:200
    IF 1:50 - 1:200
  • Validations

    Western blot - RYR2 Polyclonal Antibody

    Western blot - RYR2 Polyclonal Antibody

    Western blot analysis of extracts of mouse heart, using RYR2 antibody at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit .Exposure time: 90s.

    Immunohistochemistry - RYR2 Polyclonal Antibody

    Immunohistochemistry - RYR2 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded rat brain using RYR2 Antibody at dilution of 1:100 (40x lens).

    Immunohistochemistry - RYR2 Polyclonal Antibody

    Immunohistochemistry - RYR2 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded human placenta using RYR2 Antibody at dilution of 1:100 (40x lens).

    Immunohistochemistry - RYR2 Polyclonal Antibody

    Immunohistochemistry - RYR2 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded mouse brain using RYR2 Antibody at dilution of 1:100 (40x lens).

  • Background
    Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"