-
Product Name
RUNX2 antibody
- Documents
-
Description
RUNX2 Rabbit Polyclonal antibody. Positive WB detected in ROS1728 cells. Observed molecular weight by Western-blot: 60 kDa
-
Tested applications
ELISA, WB
-
Species reactivity
Human, Rat; other species not tested.
-
Alternative names
AML3 antibody; CBF alpha 1 antibody; CBFA1 antibody; CCD antibody; CCD1 antibody; Oncogene AML 3 antibody; OSF 2 antibody; OSF2 antibody; PEA2 alpha A antibody; PEA2aA antibody; PEBP2 alpha A antibody; PEBP2A antibody; PEBP2A1 antibody; PEBP2A2 antibody; PEBP2aA antibody; PEBP2aA1 antibody; RUNX2 antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_004348). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:2000
-
Validations
ROS1728 cells were subjected to SDS PAGE followed by western blot with Catalog No:114938(RUNX2 Antibody) at dilution of 1:600
-
Background
RUNX2, also named as AML3, CBFA1, OSF2 and PEBP2A, is a Transcription factor which involved in osteoblastic differentiation and skeletal morphogenesis. It is essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters By similarity. RUNX2 inhibits MYST4-dependent transcriptional activation. The antibody is specific to RUNX2.
-
References
- Yuan ZS, Zhou YZ, Liao XB. Apelin attenuates the osteoblastic differentiation of aortic valve interstitial cells via the ERK and PI3-K/Akt pathways. Amino acids. 47(12):2475-82. 2015.
- Chen T, Mao H, Chen C. The Role and Mechanism of α-Klotho in the Calcification of Rat Aortic Vascular Smooth Muscle Cells. BioMed research international. 2015:194362. 2015.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"