RPGRIP1 antibody

RPGRIP1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

RPGRIP1 Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells. Observed molecular weight by Western-blot: 70 kDa, 140-150 kDa

ELISA, WB

Human; other species not tested.

CORD9 antibody; DKFZp686P0897 antibody; LCA6 antibody; RGI1 antibody; RGRIP antibody; RPGR interacting protein 1 antibody; RPGRIP antibody; RPGRIP1 antibody; RPGRIP1d antibody

Rabbit IgG

This antibody was obtained by immunization of RPGRIP1 recombinant protein (Accession Number: NM_001377523). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

RPGRIP1 is a photoreceptor protein that interacts with retinitis pigmentosa GTPase regulator protein and is a key component of cone and rod photoreceptor cells. The biological functions of RPGRIP1 are complex. Mutations in this gene lead to autosomal recessive congenital blindness. In the eye, it is expressed in amacrine neurons and photoreceptors, and in numerous other tissues, albeit at greatly reduced levels. Moreover, it exists multiple isoforms with species-specific subcellular localization patterns, and the different isoforms perform cell-specific functions. Within photoreceptors, RPGRIP1 localizes predominantly to outer segments (OS) of rods and cones in humans, whereas in bovine eyes, it is found only in rod OS. In contrast, in mice, RPGRIP1 is found primarily in connecting cilia (CC), where it localizes between the ciliary axoneme and the plasma membrane. RPGRIP1 has multiple isoforms with MW 147kDa, 70-76kDa, 103kDa and 66kDa.