RORA antibody

RORA antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

RORA Rabbit Polyclonal antibody. Positive WB detected in mouse liver tissue, HeLa cells, Jurkat cells, K-562 cells, mouse kidney tissue, PC-3 cells, rat liver tissue. Observed molecular weight by Western-blot: 70-75kd

ELISA, WB

Human,Mouse,Rat; other species not tested.

DKFZp686M2414 antibody; NR1F1 antibody; Nuclear receptor ROR alpha antibody; Nuclear receptor RZR alpha antibody; RAR related orphan receptor A antibody; ROR1 antibody; ROR2 antibody; ROR3 antibody; RORA antibody; RZR ALPHA antibody; RZRA antibody

Rabbit IgG

This antibody was obtained by immunization of RORA recombinant protein (Accession Number: NM_134261). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

RORA is a steroid hormone receptor and has been implicated in the pathology of circadian rhythms, bone growth, angiogenesis, development of cones, cellular metabolism and a mediator in the immune and lipid metabolism pathways [PMID:21998696]. It binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence, which binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1 [PMID:11053433,14570920].

• Tain YL, Sheen JM, Yu HR. Maternal Melatonin Therapy Rescues Prenatal Dexamethasone and Postnatal High-Fat Diet Induced Programmed Hypertension in Male Rat Offspring. Frontiers in physiology. 6:377. 2015.