ROBO3-Specific antibody

ROBO3-Specific antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

ROBO3-Specific Rabbit Polyclonal antibody. Positive IHC detected in human gliomas tissue, human brain tissue. Positive WB detected in mouse brain tissue, SH-SY5Y cells. Observed molecular weight by Western-blot: 55kd

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

FLJ21044 antibody; HGPPS antibody; HGPS antibody; RBIG1 antibody; RIG1 antibody; ROBO3 antibody; Roundabout homolog 3 antibody; Roundabout like protein 3 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_022370). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

ROBO3 belongs to the immunoglobulin superfamily and ROBO family. ROBO3 is thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development it plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. It is required for hindbrain axon midline crossing. Defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis (HGPPS). Patients show a medulla where motor and sensory projections appear uncrossed. The antibody is specific to ROBO3.