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Product Name
ROBO1-Specific antibody
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Description
ROBO1-Specific Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 200 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
Deleted in U twenty twenty antibody; DUTT1 antibody; FLJ21882 antibody; H Robo 1 antibody; ROBO1 antibody; Roundabout homolog 1 antibody; SAX3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_002941). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:114773(ROBO1-Specific antibody) at dilution of 1:1000
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Background
ROBO1, also named as DUTT1, belongs to the immunoglobulin superfamily and ROBO family. It is a receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. It may be required for lung development. The antibody is specific to ROBO1.
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References
- Jiang Y, Yin L, Jing H, Zhang H. MicroRNA-219-5p exerts tumor suppressor function by targeting ROBO1 in glioblastoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 36(11):8943-51. 2015.
- Wen P, Kong R, Liu J. USP33, a new player in lung cancer, mediates Slit-Robo signaling. Protein & cell. 5(9):704-13. 2014.
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